Longevity Peptides
Peptides researched in the context of aging and lifespan extension.
Epithalon
Low EvidenceA tetrapeptide studied for its potential to activate telomerase and influence biological aging markers.
Thymosin Alpha-1
High EvidenceA thymic peptide approved in some countries for immune modulation, studied for viral infections and cancer adjunct therapy.
MOTS-c
Low EvidenceA mitochondrial-derived peptide studied for metabolic regulation, exercise mimetic effects, and longevity.
SS-31
High EvidenceA mitochondria-targeted peptide FDA-approved as FORZINITY (elamipretide) for Barth syndrome in September 2025 — the first FDA-approved mitochondrial-targeted therapeutic.
FOXO4-DRI
Low EvidenceA senolytic peptide designed to selectively clear senescent cells by disrupting FOXO4-p53 interaction.
Thymalin
Low EvidenceA thymic peptide preparation studied for immune system rejuvenation and age-related immune decline.
NAD+
Medium EvidenceA coenzyme essential for cellular energy production, studied for anti-aging and metabolic support.
Pinealon
Low EvidenceA short bioregulatory peptide studied for neuroprotective effects and cognitive support in aging.
Klotho (Alpha-Klotho)
Low EvidenceA naturally occurring longevity hormone (secreted alpha-klotho) being studied for cognition and brain aging; a single low-dose injection improved memory in aged monkeys, and a first-in-human Phase 1 trial in older adults is underway.
Humanin
Low EvidenceAn endogenous mitochondrial-derived peptide studied for neuroprotection, cellular stress resistance, and longevity, whose blood levels fall with age and are elevated in centenarians.
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