--- title: "5-Amino-1MQ | PepTracker Pro" url: https://peptrackerpro.com/peptides/5-amino-1mq description: "A small molecule NNMT inhibitor studied for metabolic enhancement and fat cell reduction." lang: en --- Skip to main content **Educational information only.** This site does not provide medical advice. Read full disclaimer (https://peptrackerpro.com/disclaimer) **Research-only content.** This page is for educational purposes and does not constitute medical advice. Read full disclaimer → (https://peptrackerpro.com/research-disclaimer) # 5-Amino-1MQ Low Evidence A small molecule NNMT inhibitor studied for metabolic enhancement and fat cell reduction. Aliases 5-amino-1-methylquinolinium +1 more Evidence Low Evidence Last Updated 2026-06-12 Reading Time 2 min ## What It Is 5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that sits at the intersection of SAM metabolism, NAD+ biosynthesis, and epigenetic regulation in adipose tissue. While technically not a peptide, it is widely discussed in the peptide research community due to its metabolic applications and availability through peptide-focused suppliers. NNMT methylates nicotinamide — consuming S-adenosylmethionine (SAM) in the process — and its overexpression has been associated with metabolic dysfunction, obesity, and reduced NAD+ availability. By inhibiting NNMT, 5-Amino-1MQ is proposed to increase intracellular NAD+ levels, restore SAM-dependent methylation capacity, and shift adipocyte metabolism toward energy expenditure. A landmark 2018 study demonstrated that 5-Amino-1MQ treatment increased cellular NAD+ levels by up to 40% and improved energy expenditure in adipocytes. In preclinical (mouse) models, administration reduced fat mass, improved glucose tolerance, and increased energy expenditure — even without changes in caloric intake or exercise. Notably, treated animals showed reduced adipocyte size and lower lipid accumulation without affecting lean mass. As of early 2026, no completed large-scale human clinical trials have been published, though early-phase human studies are emerging. The compound remains strictly a research tool and is not FDA-approved for any indication. Also known as: 5-amino-1-methylquinolinium, NNMT inhibitor ## Why Researchers Study It 5-Amino-1MQ targets a fundamentally different metabolic pathway than GLP-1 agonists or other weight-management compounds — NNMT-mediated NAD+ depletion in fat tissue. Its ability to increase NAD+ by 40% and improve energy expenditure without caloric restriction positions it as a mechanistically novel approach to metabolic dysfunction. Researchers are interested in whether NNMT inhibition can complement or synergize with incretin-based therapies. ## Proposed Mechanisms - Inhibits nicotinamide N-methyltransferase (NNMT) in adipose tissue - Increases intracellular NAD+ levels by up to 40% by preventing nicotinamide methylation - Restores S-adenosylmethionine (SAM) availability for epigenetic methylation reactions - Shifts adipocyte metabolism from lipid storage toward energy expenditure - Reduces adipocyte size and lipid accumulation without affecting lean body mass ## Evidence Snapshot Low Evidence Low Medium High | Study Type | Model | Outcome | Link | | --- | --- | --- | --- | | In vitro / Animal (mouse) | Adipocyte cultures and diet-induced obese mice | 40% increase in NAD+ levels; reduced fat mass and improved glucose tolerance without caloric restriction | Source: https://pubmed.ncbi.nlm.nih.gov/29514064/ | | Preclinical (mouse) | High-fat diet obesity model | Reduced adipocyte size and lipid accumulation; increased energy expenditure; no effect on lean mass | Source: https://pubmed.ncbi.nlm.nih.gov/ | ## Commonly Discussed Benefits Fat Loss: https://peptrackerpro.com/benefits/fat-loss Metabolism: https://peptrackerpro.com/benefits/metabolism Energy: https://peptrackerpro.com/benefits/energy Researching 5-Amino-1MQ? Track it, set reminders, and keep notes in the free app. Track in App (https://app.peptrackerpro.com/?add=5-amino-1mq) ## Safety & Cautions - Preclinical data only; no human clinical trials published - Not a peptide — it is a small molecule compound - Long-term safety profile not established - Not FDA-approved - Part of the 2026 'exercise mimetic' research-compound wave (alongside SLU-PP-332 and MOTS-c) marketed direct-to-consumer despite no completed human trials ## Comparisons See how 5-Amino-1MQ compares to related peptides: 5-Amino-1MQ vs AOD-9604: https://peptrackerpro.com/compare/5-amino-1mq-vs-aod-9604 5-Amino-1MQ vs MOTS-c: https://peptrackerpro.com/compare/5-amino-1mq-vs-mots-c 5-Amino-1MQ vs NAD+: https://peptrackerpro.com/compare/5-amino-1mq-vs-nad 5-Amino-1MQ vs SLU-PP-332: https://peptrackerpro.com/compare/5-amino-1mq-vs-slu-pp-332 ## Calculator Tools Use our research tools to explore dosing and reconstitution data: Reconstitution Calculator: https://peptrackerpro.com/calculators ## Citations 1. [1] Neelakantan H. et al. — Selective and membrane-permeable small molecule inhibitors of NNMT. Biochem Pharmacol. 2018 PubMed (https://pubmed.ncbi.nlm.nih.gov/29514064/) 2. [2] 5-Amino-1MQ Research Guide: NNMT Inhibition, Fat Metabolism — SourcePeptides 2026 PubMed (https://www.sourcepeptides.co/2026/05/24/5-amino-1mq-research-guide-nnmt-inhibition-fat-metabolism-what-studies-show-in-2026/) 3. [3] STAT — An obesity drug deep-dive, and peptides move mainstream (June 11, 2026) PubMed (https://www.statnews.com/2026/06/11/an-obesity-drug-deep-dive-and-peptides-move-mainstream/) ### Keep researching in the app - Log 5-Amino-1MQ to your private tracker - Set a dosing reminder - Compare it side-by-side with your stack Open PepTracker Pro Free: https://app.peptrackerpro.com/?add=5-amino-1mq Browse more peptides: https://peptrackerpro.com/peptides ## Related Peptides ### AOD-9604 Medium Evidence A modified fragment of human growth hormone studied for fat metabolism without growth-promoting effects. Fat Loss: https://peptrackerpro.com/benefits/fat-loss Metabolism: https://peptrackerpro.com/benefits/metabolism Joint Health: https://peptrackerpro.com/benefits/joint-health View Details: https://peptrackerpro.com/peptides/aod-9604 \+ Compare: https://peptrackerpro.com/compare?select=aod-9604 Track in App: https://app.peptrackerpro.com/?add=aod-9604 ### MOTS-c Low Evidence A mitochondrial-derived peptide studied for metabolic regulation, exercise mimetic effects, and longevity. Metabolism (https://peptrackerpro.com/benefits/metabolism)Fat Loss (https://peptrackerpro.com/benefits/fat-loss)Longevity (https://peptrackerpro.com/benefits/longevity)Muscle Growth (https://peptrackerpro.com/benefits/muscle-growth)+2 more View Details: https://peptrackerpro.com/peptides/mots-c \+ Compare: https://peptrackerpro.com/compare?select=mots-c Track in App: https://app.peptrackerpro.com/?add=mots-c ### NAD+ Medium Evidence A coenzyme essential for cellular energy production, studied for anti-aging and metabolic support. Energy (https://peptrackerpro.com/benefits/energy)Longevity (https://peptrackerpro.com/benefits/longevity)Anti-Aging (https://peptrackerpro.com/benefits/anti-aging)Metabolism (https://peptrackerpro.com/benefits/metabolism)+1 more View Details: https://peptrackerpro.com/peptides/nad \+ Compare: https://peptrackerpro.com/compare?select=nad Track in App: https://app.peptrackerpro.com/?add=nad ### SLU-PP-332 Low Evidence A synthetic ERRα/β/γ pan-agonist studied as an 'exercise mimetic' for endurance, fat oxidation, and metabolic health. Energy: https://peptrackerpro.com/benefits/energy Fat Loss: https://peptrackerpro.com/benefits/fat-loss Metabolism: https://peptrackerpro.com/benefits/metabolism View Details: https://peptrackerpro.com/peptides/slu-pp-332 \+ Compare: https://peptrackerpro.com/compare?select=slu-pp-332 Track in App: https://app.peptrackerpro.com/?add=slu-pp-332 ## Structured data ```json [ { "@context": "https://schema.org", "@type": "Organization", "name": "PepTracker Pro", "url": "https://peptrackerpro.com", "logo": "https://peptrackerpro.com/favicon.png", "description": "Evidence-based educational resource dedicated to improving peptide research literacy.", "contactPoint": { "@type": "ContactPoint", "email": "hello@peptrackerpro.com", "contactType": "customer support" }, "sameAs": [] }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "5-Amino-1MQ", "description": "A small molecule NNMT inhibitor studied for metabolic enhancement and fat cell reduction.", "url": "https://peptrackerpro.com/peptides/5-amino-1mq", "lastReviewed": "2026-06-12", "reviewedBy": { "@type": "Organization", "name": "PepTracker Pro Research Team", "url": "https://peptrackerpro.com" }, "isPartOf": { "@type": "WebSite", "name": "PepTracker Pro", "url": "https://peptrackerpro.com" } }, { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://peptrackerpro.com" }, { "@type": "ListItem", "position": 2, "name": "Peptides", "item": "https://peptrackerpro.com/peptides" }, { "@type": "ListItem", "position": 3, "name": "5-Amino-1MQ", "item": "https://peptrackerpro.com/peptides/5-amino-1mq" } ] }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "People researching NNMT inhibition for metabolism?", "acceptedAnswer": { "@type": "Answer", "text": "5-Amino-1MQ is a research peptide studied in preclinical models. 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