--- title: "Pain Relief Peptides | PepTracker Pro" url: https://peptrackerpro.com/benefits/pain-relief description: "Peptides studied for analgesic and pain-modulating properties." lang: en --- Skip to main content **Educational information only.** This site does not provide medical advice. Read full disclaimer (https://peptrackerpro.com/disclaimer) # Pain Relief Peptides Peptides studied for analgesic and pain-modulating properties. ### Ara-290 Medium Evidence A non-erythropoietic EPO analog studied for nerve repair and neuropathic pain conditions. Nerve Repair: https://peptrackerpro.com/benefits/nerve-repair Pain Relief: https://peptrackerpro.com/benefits/pain-relief Inflammation: https://peptrackerpro.com/benefits/inflammation Recovery: https://peptrackerpro.com/benefits/recovery View Details: https://peptrackerpro.com/peptides/ara-290 \+ Compare: https://peptrackerpro.com/compare?select=ara-290 Track in App: https://app.peptrackerpro.com/?add=ara-290 ### BPC-157 Medium Evidence A pentadecapeptide derived from human gastric juice, studied for tissue repair and gut-protective properties. Recovery (https://peptrackerpro.com/benefits/recovery)Gut Health (https://peptrackerpro.com/benefits/gut-health)Wound Healing (https://peptrackerpro.com/benefits/wound-healing)Joint Health (https://peptrackerpro.com/benefits/joint-health)+2 more View Details: https://peptrackerpro.com/peptides/bpc-157 \+ Compare: https://peptrackerpro.com/compare?select=bpc-157 Track in App: https://app.peptrackerpro.com/?add=bpc-157 ### Difelikefalin High Evidence Difelikefalin (Korsuva in the U.S., Kapruvia in Europe) is a synthetic tetrapeptide built entirely from D-amino acids - D-Phe-D-Phe-D-Leu-D-Lys capped with a 4-aminopiperidine-4-carboxylic acid - that acts as a selective agonist at the kappa opioid receptor. Its defining property is what it cannot do: the molecule is hydrophilic and bulky enough that it does not meaningfully cross the blood-brain barrier, so it reaches kappa receptors on peripheral sensory nerve endings, keratinocytes and immune cells while leaving the central kappa receptors that produce dysphoria and hallucinations largely untouched. It has no activity at the mu opioid receptor, so it carries neither euphoria nor respiratory depression. In the Phase 3 KALM-1 and KALM-2 trials in hemodialysis patients with moderate-to-severe chronic-kidney-disease-associated pruritus, roughly 40-51% of difelikefalin-treated patients achieved a clinically meaningful (>=3-point) reduction on the 10-point Worst Itching Intensity NRS at 12 weeks versus roughly 20-28% on placebo. The FDA approved intravenous difelikefalin in August 2021; the EU approved it as Kapruvia in April 2022. Pain Relief (https://peptrackerpro.com/benefits/pain-relief)Inflammation (https://peptrackerpro.com/benefits/inflammation)Skin (https://peptrackerpro.com/benefits/skin)Disease Modification (https://peptrackerpro.com/benefits/disease-modification)+1 more View Details: https://peptrackerpro.com/peptides/difelikefalin \+ Compare: https://peptrackerpro.com/compare?select=difelikefalin Track in App: https://app.peptrackerpro.com/?add=difelikefalin ### DSIP Low Evidence A neuropeptide studied for its role in sleep regulation and stress modulation. Sleep: https://peptrackerpro.com/benefits/sleep Mood: https://peptrackerpro.com/benefits/mood Anxiety Relief: https://peptrackerpro.com/benefits/anxiety-relief Pain Relief: https://peptrackerpro.com/benefits/pain-relief View Details: https://peptrackerpro.com/peptides/dsip \+ Compare: https://peptrackerpro.com/compare?select=dsip Track in App: https://app.peptrackerpro.com/?add=dsip ### Pentosan Polysulfate High Evidence A semi-synthetic polysaccharide FDA-approved for interstitial cystitis and studied for joint health applications. Joint Health: https://peptrackerpro.com/benefits/joint-health Inflammation: https://peptrackerpro.com/benefits/inflammation Pain Relief: https://peptrackerpro.com/benefits/pain-relief View Details: https://peptrackerpro.com/peptides/pentosan-polysulfate \+ Compare: https://peptrackerpro.com/compare?select=pentosan-polysulfate Track in App: https://app.peptrackerpro.com/?add=pentosan-polysulfate Track Your Research with PepTracker Pro Try the Free App → (https://app.peptrackerpro.com/)